Magnetic Resonance Imaging of Animal Brain In Vivo
نویسندگان
چکیده
As a non-invasive tool for mapping anatomical and functional aspects of the central nervous system, magnetic resonance imaging (MRI) reduces the number of animals in follow-up examinations and refines the quality of the results by yielding in vivo data of individual animals over extended time periods. Although applications cover the full range from non-human primates to insects, the vast majority of MRI studies focuses on rodents. This work illustrates selected applications in mice based on three-dimensional images at almost 100 μm isotropic spatial resolution. A primary aim is a better understanding of the pathophysiological mechanisms underlying human brain disorders. In this respect, the cuprizone mouse model allows the identification of MRI markers for demyelination and remyelination. Complementary, the use of transgenic mice with a Cnp1 deficiency in oligodendrocytes adds selective MRI studies of axonal damage without demyelination. A second goal is the functional assessment of synaptic activity and axonal transport in various brain systems using manganese-enhanced MRI. The contrast agent identifies activity-dependent regional differences in the mouse hippocampus and delineates the efferent pathways to the ventral hippocampal commissure and septal region. While opening the way for investigations of memory and learning in mutant mice, corresponding studies of the habenulo-interpeduncular system provide links to cognition and behaviour and the mechanisms of neuropsychiatric diseases.
منابع مشابه
CLINICAL CORRELATIONS BETWEEN AUDITORY BRAIN STEM RESPONSE AND MAGNETIC RESONANCE IMAGING IN PATIENTS WITH DEFINITE MULTIPLE SCLEROSIS
In an attempt to assess objectively the integrity of the auditory pathways in 30 patients with definite multiple sclerosis (MS), an audiometric evaluation was performed and auditory brainstem responses (ABRs) were obtained. Stressing the auditory system by increasing the stimulation rate showed some enhancement in the identification of MS. 24 (RO%) patients had an abnormal ABR along with c...
متن کاملSegmentation of Magnetic Resonance Brain Imaging Based on Graph Theory
Introduction: Segmentation of brain images especially from magnetic resonance imaging (MRI) is an essential requirement in medical imaging since the tissues, edges, and boundaries between them are ambiguous and difficult to detect, due to the proximity of the brightness levels of the images. Material and Methods: In this paper, the graph-base...
متن کاملPseudo-CT Generation from Magnetic Resonance Imaging by fuzzy look up table algorithm
Introduction: Despite growing interest in the use of magnetic resonance imaging (MRI) in the external radiotherapy design process (RT), Computer Tomography (CT) remains a gold standard and is regarded as a basic imaging modality in radiotherapy. MRI shows the high contrast in soft tissues without any radiation exposure to patients. As a result, MRI is used in functional tissue ...
متن کاملUsing functional magnetic resonance imaging (fMRI) to explore brain function: cortical representations of language critical areas
Pre-operative determination of the dominant hemisphere for speech and speech associated sensory and motor regions has been of great interest for the neurological surgeons. This dilemma has been of at most importance, but difficult to achieve, requiring either invasive (Wada test) or non-invasive methods (Brain Mapping). In the present study we have employed functional Magnetic Resonance Imaging...
متن کاملUsing functional magnetic resonance imaging (fMRI) to explore brain function: cortical representations of language critical areas
Pre-operative determination of the dominant hemisphere for speech and speech associated sensory and motor regions has been of great interest for the neurological surgeons. This dilemma has been of at most importance, but difficult to achieve, requiring either invasive (Wada test) or non-invasive methods (Brain Mapping). In the present study we have employed functional Magnetic Resonance Imaging...
متن کاملEffect of Bias in Contrast Agent Concentration Measurement on Estimated Pharmacokinetic Parameters in Brain Dynamic Contrast-Enhanced Magnetic Resonance Imaging Studies
Introduction: Pharmacokinetic (PK) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely applied in tumor diagnosis and treatment evaluation. Precision analysis of the estimated PK parameters is essential when they are used as a measure for therapy evaluation or treatment planning. In this study, the accuracy of PK parameters in brain DCE...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006